Farida. Nuraini Primary Author mixed material bibliography Surabaya Universitas Airlangga 1988 monographic id Indonesia

Text

xvi, 109p.; 30,5cm Phenytoin kinetics was studied in 20 patients at the Neurologica Clinic Dr. Soetomo Hspital (12 males, 8 females). the patients were 18-42 years old, weighing 40-77 kg with normal hepar and renal function. at least 2 weeks before the study, the patients had to be free from other drugs especially those drug which can influence Phenytoin metabolism. the patients were given three different dosages consecutively 200 mg, 300 mg and 400 mg. each dosage was given for a period of three weeks. plasma samples were taken just before the next dose at the last three days of each dosage period. Phenytoin concentration in plasma was determined by UV spectrophotometry (modified Wallace method); the technique was based upon the oxidation of the parent drug to Benzophenone. the result was a large variation of Phenytoin level; plasma Phenytoin levels obatained were 4.84-13.90 ug/ml at the 200 mg dossage/ 8.78-30.49 ug/ml at the 300 mg dossage and 18.25-53.61 ug/mil at the 400 mg dossage. Large variations were also observed in the relationship between Phenytoin plasma level and clinical effect. subtherapeutic effect occured on C_ss^min = 4.84 - 17.83 ug/ml and therapeutic effect on C_ss^min = 12.21 - 23.73 ug/ml. on C_ss^min more than 25 ug/ml toxic effects were observed such as nystagmus and ataxia. there is a large interindividual difference between plasma level of Phenytoin and its pharmacological effect. Vmax range was 220-1880.00 mg/day (807.50 ± 407.74 mg/day) and Km range was 5.00 - 8.00 ug/ml (28.23 ± 19.53 ug/ml). Vmax and Km were not influenced by sex (α=0.01 ; df=1). because of the ratio Css/km = 0.107 - 3.832 Km (between 0.1 - 10 Km) and the increase of Phenytoin plasma concentrations were not proportional to the dose, the study conclded nonlinier Phenytoin kinetics in 19 or 95% of thebpatients were already observed at the 200 mg dossage; in 1 or 5% of the patients nonlinier kinetics began at the 300 mg dossage. EPILEPTION 6B.T Far f PERPUSTAKAAN FAKULTAS FARMASI - UNIVERSITAS HANG TUAH Jl. Arief Rachman Hakim 150 , Surabaya 60111 Telp: (031) 5945864, 5945894 Fax : (031) 5946261 , Web. www.hangtuah.ac.id 6B.T Far f FARM28-6B.T-2015 Perpus Farmasi (Rak Tesis) 6B.T Far f Tesis_Nuraini_Farida.jpg.jpg 444 2015-11-03 08:27:58 2015-11-04 09:55:34 machine generated